Abstract
To investigate a recent report suggesting extensive bone erosion (EBE) as an important prognostic factor in head and neck rhabdomyosarcoma, a retrospective review was performed of 32 patients with gross residual and/or metastatic non-orbital head and neck rhabdomyosarcoma treated between the years 1971–1987. Treatment consisted of surgery, radiation therapy (median primary dose, 5000 cGy) and combination chemotherapy according to the Memorial Sloan-Kettering Cancer Center (MSKCC) T2 and T6 protocols. The MSKCC staging system was used: Stage II, 23 patients; Stage III, 6 patients; and Stage IV, 3 patients. With a median follow-up of 48 months range 17 months to 13 years), the overall survival and local control rates were 72% ( 23 32 ) and 75% ( 24 32 ), respectively. Local control was achieved in 11 11 patients without extensive bone erosion (Stages II, 9 9 ; III, 1 1 ; IV, 1 1 )as compared to 13 21 patients (Stages II, 10 14 ; III, 2 5 ; IV, 1 2 ) with extensive bone erosion ( p = 0.02). Our data appear to support the recently reported finding that extensive bone erosion is an important predictor of local failure.
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