Abstract
ABSTRACT The following findings were obtained which bear on the mechanisms concerned in the rise of plasma free 17-hydroxycorticoid (17-OHCS) levels in patients treated with estrogenic hormone (ethinyl estradiol or diethylstilbestrol): 1) Cortisol accounted for approximately 80 per cent of the plasma free 17-OHCS in a normal subject given estrogen. 2) In patients treated with estrogenic hormone there was a marked rise in the level of plasma free 17-OHCS but no increase in urinary total 17-OHCS excretion. 3) In a man with intact adrenals who received ACTH intravenously and in an Addisonian woman who received cortisol intravenously there was a greater rise in the level of plasma free 17-OHCS and urinary F + E but a lesser rise in urinary THF+THE when estrogen was also administered. 4) On three occasions when patients with adrenal insufficiency were given cortisol intravenously, estrogen produced a diminished rate of removal of free 17-OHCS from plasma and a smaller distribution volume of the injected F. 5) ...
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