The influence of environmental factors on the kinetics of a biosynthetic process

Abstract

The efforts of specialists in the kinetics of biosynthetic processes are concentrated on the investigation of kinetic relations depending on a limiting stage of the process (diffusive or kinetic). If a kinetic study is needed, then the kinetics of the process in relation to the limiting component (substrate or a metabolic product) is investigated. The influence of environmental factors, whether thermodynamic (temperature, pressure) or parametric (pH and oxidation-reduction potential), is usually not considered. Investigations were carried out on the influence of temperature on the rate of formation and decay of an enzyme using the Arrhenius equation, on the influence of pH enzyme dissociation and on substrate rate of formation and decay in different stages of substance transformation into the cell material. These relations were generalized by a mathematical dependence of the growth rate on environmental temperature and pH value.