Abstract
Both genetic and environmental factors have been implicated in the mechanism of various disorders. Epidemiological data have shown that environmental factors can also cause and/or exacerbate the pathogenesis of these diseases. However in this article, we provide a summary of evidence for environmental and genetic factors influencing the diseases. The review also incorporates the major findings categorizing the common diseases on the basis of genetic profiles and ethnic information and in establishing personalized disease diagnosis, drug responses and treatment modalities based on the genetic determinants. These studies provide important insights into the interplay between environmental and genetic factors leading to human diseases. Overall an attempt has been made to highlight the importance of studying the genetic profiles of an individual with many factors.
Highlights
Basic biology of genetic syndromesA genetic syndrome is any disease that is caused by an abnormality in an individual’s genome
While some diseases, such as cancer, are due in part to genetic disorders, they can be caused by environmental factors
If a disease process is concluded to be the result of a combination of genetic and environmental factor influences, its etiological origin can be referred to as having a multifactorial pattern
Summary
A genetic syndrome is any disease that is caused by an abnormality in an individual’s genome. A genetic disorder is an illness caused by abnormalities in genes or chromosomes. While some diseases, such as cancer, are due in part to genetic disorders, they can be caused by environmental factors. Some types of recessive gene disorders confer an advantage in the heterozygous state in certain environments. Environmental factors such as the weather affect business interests. If a disease process is concluded to be the result of a combination of genetic and environmental factor influences, its etiological origin can be referred to as having a multifactorial pattern. Many cancers along with a plethora of other diseases, are thought to be a result of environmental triggers (Figure 1)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
