Abstract
Attention has been called to the influence of the endocrine system on anaphylactic reactions by the experiments of Lanzenberg and Kepinow (1). They showed that thyroidectomy lessened the anaphylactic reactions of guinea pigs sensitized and shocked with horse serum. Wolfram and Zwemer (2) have shown that adrenocortical extract (cortin) protected guinea pigs against anaphylactic shock, when administered a few hours prior to the injection of the shocking dose. The present report contains data that have been arrived at from a study of the effect of anterior pituitary extract (A.P.E.), pregnancy urine extract (P.U.) and follicular hormone on anaphylactic reactions in guinea pigs. Special attention was paid to A.P.E., due to its known effects on the thyroid, gonads and adrenal glands. The effect of A.P.E. on the histology and physiology of the thyroid and the accompanying changes in the basal metabolic rate has been observed by many investigators. Friedgood (3) noted the effect of daily administration of A.P.E....
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