Abstract
The present study was undertaken to examine the effect of electroshock on adrenoceptor-mediated cAMP and inositol phosphate accumulation in rat brain cerebral cortical slices. Under the conditions of these experiments, isoproterenol-induced cAMP accumulation was unaltered by electroschock, although there was a significant reduction in the norepinephrine- and isoproterenol + 6-fluoronorepinephrine-stimulated responses. No change in α-adrenoceptor-mediated inositol phosphate accumulation was noted. The results indicate that electroshock selectively modifies an α-adrenoceptor system in brain that differs from that associated with inositol phosphate accumulation.
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