Year-end Sale % OFF 
Abstract
Accurate temperature and thermal dose prediction are crucial to high-intensity focused ultrasound (HIFU) hyperthermia, which has been used successfully for the non-invasive treatment of solid tumors. For the conventional method of prediction, the tissue properties are usually set as constants. However, the temperature rise induced by HIFU irradiation in tissues will cause changes in the tissue properties that in turn affect the acoustic and temperature field. Herein, an acoustic–thermal coupling model is presented to predict the temperature and thermal damage zone in tissue in terms of the Westervelt equation and Pennes bioheat transfer equation, and the individual influence of each dynamic tissue property and the joint effect of all of the dynamic tissue properties are studied. The simulation results show that the dynamic acoustic absorption coefficient has the greatest influence on the temperature and thermal damage zone among all of the individual dynamic tissue properties. In addition, compared with the conventional method, the dynamic acoustic absorption coefficient leads to a higher focal temperature and a larger thermal damage zone; on the contrary, the dynamic blood perfusion leads to a lower focal temperature and a smaller thermal damage zone. Moreover, the conventional method underestimates the focal temperature and the thermal damage zone, compared with the simulation that was performed using all of the dynamic tissue properties. The results of this study will be helpful to guide the doctors to develop more accurate clinical protocols for HIFU treatment planning.
Highlights
Cancer is one of the serious diseases that threatens the life and health of humans
The influence of each dynamic tissue property on high-intensity focused ultrasound (HIFU) hyperthermia is studied independently based on the reported experimental data of dynamic tissue properties
It is worth mentioning that the maximum focal temperature for dynamic Kliver is lower than that for constant Kliver, but the thermal damage zone is almost the same for dynamic Kliver and constant Kliver
Summary
Cancer is one of the serious diseases that threatens the life and health of humans. According to cancer statistics released by the National Cancer Center of China, 3.804 million new cancer cases were diagnosed and 2.296 million cancer deaths were reported in 2014 [1]. HIFU therapy is a non-invasive technology in which an ultrasound beam carries sufficient energy, and the energy is focused onto the target area to cause a local temperature rise, which is sufficiently high to make the lesion tissue undergo coagulative necrosis without causing damage to the overlaying or surrounding tissue [4,5] It has many advantages such as non-invasive, non-contact, non-ionization, and low cost [6,7], and has been successfully used in clinics to treat solid malignant tumors, including cancers of the prostate, liver, kidney, breast, and pancreas [8]. We develop an acoustic–thermal model to evaluate the joint effect of all of the dynamic tissue properties on temperature distribution and thermal damage, including sound speed, acoustic absorption coefficient, non-linearity parameter, specific heat capacity, thermal conductivity, density, and blood perfusion. The results provide a more accurate prediction of temperature distribution and thermal damage, gaining insight into the complex dynamic processes during HIFU hyperthermia, which are useful for doctors making treatment planning
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
