The influence of different degrees of obstructive sleep apnea hypopnea syndrome associated on cognitive function

Abstract

Objective To explore the influence of different degrees of obstructive sleep apnea hypopnea syndrome (OSAHS) associated on cognitive function. Methods 86 hospitailized patients with OSAHS diagnosis standard by our department polysomnography were collected.According to apnea hypopnea index (AHI), they were divided into the mild-moderate and severe groups.And then we compared two groups of Montreal cognitive assessment scale (MoCA) results, event related potential (ERP) ingredients in P300 latency period, the brain volume of hippocampal atrophy and cerebral white matter lesions related focal high signal around the lateral ventricle which measured by regular craniocerebral MRI sequence and perpendicular to the bilateral hippocampal fluid attenuated inversion recovery (FIAIR) sequence. Results The MoCA total score of the severe group was significantly lower than the moderate group′ and so did the scores of in memory′ attention′ execution′ability (P<0.05), but there was no significant difference in the rest of cognitive field.The P300 latency period of the severe group was significantly longer than the moderate group (P<0.05). With the severity of OSAHS aggravated, hippocampal volume atrophy and PVH showed a trend of increase, the severe group was significantly higher than the moderate group (P<0.05). Conclusions Compared with moderate patients′ the cognitive function of severe patients with OSAHS which is mainly reflected in the memory′ attention′ execution′ability, and its corresponding brain structure and function are affected at the same time, its can provide early and objective basis for OSAHS′ cognitive impairment diagnosis. Key words: Obstructive sleep apnea hypopnea syndrome; Cognitive impairment; Montreal cognitive assessment scale; P300 latency period; Hippocampus; White matter