Abstract
The effects of dietary vitamin A status on fluidity and composition of rat liver microsomes were investigated. Fluidities of membranes and liposomes prepared from microsomal lipids were decreased by both privation and excess of vitamin A. This structural change was associated with a lower phospholipid/cholesterol ratio in deficient rats and with higher saturated/unsaturated fatty acid ratio and a lower phosphatidylcholine/sphingomyelin ratio in the hypervitaminosis group.
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