Abstract
The objective of the study was to analyze the characteristics of the patients with preserved ejection fraction heart failure (HfpEF) who develop hyponatremia, in relationship with the diabetes mellitus (DM). The current study is an observational retrospective one, that included 36 patients(25 women, 11 men), aged 66.6� 3.1 years, hospitalized for decompensated chronic heart failure, with a left ventricular ejection fraction ]40%. 33% (n=12) of the enrolled patients had hyponatremia, which was strong associated with DM (75% vs 17%, p[0.0005). In hyponatremic patients group was no association between DM and age, gendre, smoking, artrial hypertension, dyslipidemia, ejection fraction distribution or NTproBNP. As for medication at admission, we found an association of the presence of DM with betablockers(100% vs 67%, p[0.05) and with statins( 89% vs 67%, p[0.05). In our study, DM and non-DM patients with low serum sodium values and HfpEF have quite similar clinical profile, since the differences we found do not explain the high prevalence of DM in hyponatremic patients. As a conclusion, the presence of DM itself may explain the high prevalence of DM in hyponatremic patients, but is necessary to have larger studies with more variables included to assess HFpEF patients with DM and hyponatremia.
Highlights
The objective of the study was to analyze the characteristics of the patients with preserved ejection fraction heart failure (HfpEF) who develop hyponatremia, in relationship with the diabetes mellitus (DM)
Hyponatermia is a very frequent electrolyte imbalance in heart failure patients (18-30% acording to Rusinaru et al [1]), the percentage being similar between those who present preserved left ventricular ejection fraction and those who present reduced left ventricular ejection fraction
In a study with heart failure patients included regardless ejection fraction hyponatremia was correlated only with insulin use, and not with oral antidiabetic agents [24].The percentage of patients with DM in hyponatremic patients was pretty high in our study and it is necessary to mention that we had a small basis of patients which included patients with an ejection fraction between 40-50% and there are only patients evaluated during hospitalization
Summary
The objective of the study was to analyze the characteristics of the patients with preserved ejection fraction heart failure (HfpEF) who develop hyponatremia, in relationship with the diabetes mellitus (DM). Hyponatremia has negative prognosis even for patients with preserved ejection fraction heart failure [1,2].
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