Abstract
Compensatory renal hypertrophy in the renoprival kidney of Charles River mice and the effect of dactinomycin on this process were studied. Increases in animal weight, wet kidney weight, total protein, and bulk nucleic acid occurred as early as 12 hr postnephrectomy and continued throughout the 28-day period. Dactinomycin inhibited compensatory renal hypertrophy for 7 days. This effect was transient and after an initial lag, accelerated growth rates were observed. By 28 days growth parameters in the dactinomycin-treated animals equaled those of control animals undergoing compensatory renal hypertrophy.
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