Abstract
Objective To investigate the effect of curcumin and irinotecan on colorectal cancer Lovo cells.Methods Methyl thiazol tetrazolium (MTT) assay and flow cytometry were used to detect the proliferation activity and apoptosis rate of Lovo cells treated by different concentrations of curcumin and irinotecan alone or in combination at different time points.Results Curcumin and irinotecan inhibited the proliferation of Lovo cells both in time-and dose-dependent manner.The inhibition rate of Lovo cells in curcumin + irinotecan combined group with mixed administration was significantly higher than in curcumin group or irinotecan group (P ＜ 0.01),and that in two experimental groups with sequential administration was significantly higher than in control group (P ＜ 0.05).As compared with the mixed administration group,the apoptosis rate of Lovo cells was increased significantly in the sequential administration groups.Conclusion Both curcumin and irinotecan can inhibit the proliferation of Lovo cells time-dose dependently,and exert the synergic effects.Compared to the mixed administration,the sequential administration can enhance the inhibitory effect on Lovo cells. Key words: Curcumin; Irinotecan; Colorectal carcinoma
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