Abstract
Collateral circulation in the left limb was developed in adult rabbits by ligation of the femoral artery, after which below knee amputation was performed at various time intervals. The muscle blood flow (MBF) was assessed by 133 Xenon and Histamine. The investigation showed that the length of time between the two operations strongly influenced the function of the collaterals. Simultaneous ligation of the artery and amputation resulted in a prolonged reduction in MBF, whereas amputation 3 days after ligation of the artery resulted in an immediate increase in blood flow in the amputation stump. A 10-week interval between arterial occlusion and amputation gave an initial reduction in blood flow.
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