Abstract
AbstractChlorpromazine was administered to normal rats placed at 30° and 20° C and to cold acclimated rats exposed to 30° and 2°. Treatment of the animals at 30° produced no increase in catecholamine excretion. However, rats placed at either 20° or 2° significantly increased their noradrenaline excretion, and to a lesser extent their adrenaline excretion, following chlorpromazine. These increases, also noted in adrenalectomized rats and associated with hypothermia, could be prevented by pretreatment with a ganglionic blocker. It is concluded that the increase in noradrenaline excretion is a result of a temporary hypothermia produced by chlorpromazine and originates from sympathetic nerve endings.
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