The influence of chlorpromazine and octoclothepine on the incorporation of 14C-glycine into brain and liver proteins in mice

Abstract

A single intravenous injection of chlorpromazine or octoclothepine (10 mg/kg) enhanced the in vivo incorporation of labeled glycine into brain and liver proteins. The stimulation may be blocked by the application of actinomycin C or by adrenalectomy. Chlorpromazine and octoclothepine at a concentration of 10 −3 M inhibited protein synthesis of brain and liver slices by approximately 50%. Brain cells accumulated glycine against a concentration gradient. The active transport was inhibited by both drugs at 10 −4 − 10 −3 M. Liver cells do not accumulate glycine and the passage into the cells was not affected by the drugs.