Abstract
Summary Bacteriological and histological examinations were made on 71 specimens of lung tissue from 68 patients with pulmonary tuberculosis. In 11 the sputum was positive at the time of examination and the organisms were resistant to the drugs in use. In 55 the sputum was negative and the organisms had been sensitive to the drugs in use when last tested. In 2 the sputum was positive and the organisms drug-sensitive. Drug-sensitivity seems to play a major part in the sterilization of tuberculous lesions. Provided that the organisms are sensitive to the drugs in use, the longer chemotherapy is given the less is the likelihood of viable bacilli being isolated. There was close correlation between the healing of cavity walls, both on naked-eye appearance and histologically, and the results of bacteriological examination of the lesion. Some comments are made on the relationship between positivity and the size, consistency and histological activity of the lesions.
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