Abstract
Snakehead fish (Channa striata) have high albumin content, a protein needed for cell development and the formation of new tissue. The aim of this study was to determine the influence of snakehead fish extract emulgel given topically on incision wounds in white rats. The parameters of wound healing consist of wound length, a number of neutrophils, macrophages, fibroblasts and density of collagen. The white rats divide into three groups of (n = 6), one group was given the emulgel base as the negative control, one group of povidone-iodine as the positive control, and one group of snakehead fish extract 10% emulgel. White rats were sacrificed on the third and seventh days for microscopic observations. The results showed that snakehead fish extract emulgel can accelerate incision wound healing: decrease wound length, increase the number of neutrophil and macrophages cells, increase the average number of fibroblasts and increase collagen density on white rats.
Highlights
Open wounds are wounds that visible to where the blood comes out of the body
The aim of this study was to know the influence of Channa striata extract emulgel on white rat incision wounds healing with the parameters, the number of neutrophils, macrophages, fibroblasts, and collagen density
The wound healing involves some stages in the process
Summary
Open wounds are wounds that visible to where the blood comes out of the body. A deeper incision includes the lining of the muscularis, blood vessels, nerves, and tendons (Nagori dan Solanki, 2011). The wound healing process consists of four phases: hemostasis, inflammation, proliferation, and remodeling. The wound response occurs so blood vessels themselves constrict and platelets secrete to form a stable clot that sealing the damaged blood vessels. The inflammatory response is the second phase that occurs since the blood vessels leak and expel plasma and neutrophils into the tissues. In the proliferation phase which lasts for 4 to 21 days, angiogenesis, collagen tissue deposition, granulation tissue formation, and wound contraction and epithelization occur. The healing process involves remodeling and realignment of the collagen tissue to produce greater tensile strength. The main cells that play a significant role in this process are fibroblasts (Orstedv et al, 2011)
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