Abstract
Publisher Summary This chapter discusses the influence of capillary blood flow on O2 transport dynamics in brain nervous tissue. The functioning of the brain nervous tissue is accompanied by fast and considerable circulation rate alterations in capillaries. Therefore, it seems important to know the effect of the blood flow fluctuations on the dynamics of oxygen supply in brain nervous tissue. The chapter discusses a study in which the method of mathematical simulation was used to develop a model that broadened considerably outlook on the statistical O2 partial pressure distribution in brain microspace, by taking into account the complicacy of O2 transport processes in brain. Calculations were carried out on an idealized construction of capillary network and nerve globe cell and on real constructions obtained as a result of morphological research of rat cerebral cortex. In this model, the experimental data about capillary network density, circulation rate in capillaries, nerve cells, and surrounding tissue O2 consumption, and O2 diffusion and solubility coefficient in blood and brain were taken into account.
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