Abstract
The early temporal (0–2 hr) effects of porcine thyrocalcitonin and salmon ultimobranchial calcitonin were studied in intact rats administered both 45Ca and 32P either 2 weeks before (long-range label) or S min after (shortrange label) sc injection of hormone. Effects of calcitonins on plasma calcium, 45Ca and SA were similar to those reported previously by numerous workers and thereby could be explained by the concept that these hormones act primarily by inhibiting entry of calcium into the plasma. A minor increase in the rate of calcium exit from plasma, has been reported previously, and was also observed in the present study. Effects of calcitonins on 32P were in marked contrast to those on 45Ca. By 20 min after hormone administration, concentrations of both phosphate and 32P in plasma were significantly lower than in control animals and by 1 hr, reached levels 25% less than those in controls. The same results occurred in both short- and long-range experiments. Since both plasma phosphate and 32P fell c...
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