Abstract
In this study, a novel gold-coated test strip for blood glucose measurement has been designed. Such gold-coated test strip is feasible for mass production to achieve economies of scale. Cyclic voltammetry was applied to test strips to undergo electrochemical reaction under a potential range of ±0.4 V. Glucose oxidase (GOD) was added into K3[Fe(CN)6]. When glucose oxidase undergoes electrochemical reaction, the medium, K3[Fe(CN)6], will act as an electron acceptor, causing the electrodes on the test strip to generate a pair of clear anodic and reductive peaks. The maximum of the anodic and reductive peaks can be used as reference to adjust the resistance of the blood glucose meter. The experimental results show that by adjusting the resistance of the blood glucose meter, the accuracy of blood glucose meter reading can be tuned and blood glucose reading can be stabilized. Therefore, when the resistance of the blood glucose meter is at 2.4 KΩ, the standard deviation (STD) and coefficient of variation (CV) of the test strip are lower than those of the test strips measured at resistances of 2.2 KΩ and 2.6 KΩ. It has been proved in this study that adjusting the resistance of the blood glucose meter can optimize the chemical reaction on gold-coated test strips as well as its reading. This method can also be applied to tune the accuracy of readings for test strips coated with other materials.
Highlights
A blood glucose meter uses blood glucose test strips to measure the blood glucose level of a diabetic patient
The reaction zone on the electrode of the blood glucose test strip is covered with glucose oxidase, which allows electrons formed in-between the oxidase and electrode surfaces to be transported to the biochemical sensor [5, 6]
Blood glucose meter adjusted the resistance of R3 according to the current change from cyclic voltammetry electrochemical reaction
Summary
A blood glucose meter uses blood glucose test strips to measure the blood glucose level of a diabetic patient. The electrode-sensing circuit of the biochemical sensor typically is made from screen-printed carbon paste which acts as the base material for the test strip. Such carbon paste-coated test strip has been widely used in clinical tests for measuring the blood glucose level of diabetic patients [7]. In this study, an effective method was proposed to create an excellent oxidase-based sensing test strip. In this test strip, gold-coated electrode was adopted as the base material since gold has good conductivity and is quite stable.
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