Abstract
In order to improve the capacity of simvastatin and extend the time of the release of the drug, this experiment adopts bionic-deposition to decorate a layer of octacalcium phosphate (OCP) on the face of TiO2 nanotube array,and respectively discusses what are the appropriate parameters of octacalcium phosphate (OCP) can be generated. Experiments show that loading a layer of octacalcium phosphate can extend the time of the release of the drug. In addition, the presence of simvastatin on the TiO2 nanotube array will be a certain influence on the morphology of octacalcium phosphate. However, simvastatin can be dissolved into the bionic fluid by using bionic deposition. Therefore, by step concentration soaking and then using this method to load OCP with simvastatin can effectively improve the amount of simvastatin loaded and extend drug release
Highlights
The inertia of pure titanium can cause the failure of implant, so it is necessary to modify the surface of pure titanium, through the process of anodic oxidation to create a layer of TiO2 nanotube array can improve the biocompatibility of pure titanium
Calcium phosphate is familiar to the form of human's bone, especially like hydroxyapatite and octacalcium phosphate(OCP) are main component of human's body tissue, the existence of Ca-P salt on the surface of TiO2 nanotube array is in favor of the formation of new bone tissue around transplant material, it is benefit to osseointegration between titanium replacement and new bone
Curve a is for amorphous TiO2 nanotubes, Curve b is for the mixed phase of anatase/rutile
Summary
The inertia of pure titanium can cause the failure of implant, so it is necessary to modify the surface of pure titanium, through the process of anodic oxidation to create a layer of TiO2 nanotube array can improve the biocompatibility of pure titanium. Calcium phosphate is familiar to the form of human's bone, especially like hydroxyapatite and octacalcium phosphate(OCP) are main component of human's body tissue, the existence of Ca-P salt on the surface of TiO2 nanotube array is in favor of the formation of new bone tissue around transplant material, it is benefit to osseointegration between titanium replacement and new bone. Biomimetic Ca-P layer can improve the biocompatibility and modify the reactivity on the surface of implant, and increase the binding force between implant and bone tissue, which has been widely applied in dental implant. This experiment use biomimetic technique to load a layer of ca-p salt on the surface of TiO2 nanotube array to modify the nanotube. Using degradative OCP to modify the surface of nanotube can prevent the explosive release of the drug, and let simvastatin to be released slowly with the degradation of Ca-P salt
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