The Influence of ATP Synthase 8, 6 Gene Polymorphisms on the Individual Difference of Endurance Capacity or its Trainability

Abstract

The purpose of the present study was to investigate the relationship between the polymorphisms of ATP synthase 8, 6 gene and the individual difference of the endurance capacity or its trainability. Sixty-nine sedentary adult males participated in an 8-week endurance training program and VO2max and ventilatory threshold (VT) was determined as the index of endurance capacity before and after training. The polymorphisms of ATP synthase 8, 6 genes were determined by direct sequence on total DNA that was extracted from venous blood. The VO2max increased from 41.7 to 47.8ml/min/kg (P<0.01), and VT increased from 26.9±5.6ml/min/kg to 31.9±6.8ml/min/kg (P<0.01). The polymorphism at 25 sites was detected in ATP 8, 6 gene. At mtDNA 8701, non-Cam group (n=50: VT/w=27.8±5.3ml/min/kg) had higher pre VT/wt than Cam group (n=19: VT/w=24.3±5.5ml/min/kg). The comparison of pre VT/LBM between Cam group and non-Cam group at mtDNA 8701 was also similar. We concluded that mtDNA ATP synthase 8, 6 gene might be associated with the individual difference in initial level of VT.