Abstract
Summary Chlorpromazine, ethanol, 1,3-propanediol and Na lauryl sulfate evoke a pronounced decrease of red cell deformability. This could be demonstrated with two different techniques: red cell filtration and viscosity measurements. These compounds represent different groups of drugs with anesthetic and membrane stabilizing properties. It was shown that the effect of these compounds on red cell deformability should be attributed to a drug-membrane interaction, presumably resulting in a conformation change of membrane proteins.
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