Abstract
Vascular function may be impacted by the known elevation of oxidative stress in COPD. Surprisingly, little is known about the importance of these phenomena on the pathology of this disease. This study aimed to characterize vascular function measured by flow‐mediated vasodilation (FMD) in patients with COPD and determine the effect of an antioxidant cocktail (AOC). Patients (ages 69–79 yrs) performed a pulmonary function test to determine disease severity. In a randomized, double‐blind, experimental design (2 days), FMD was evaluated following the ingestion of either a placebo or an AOC. Both the placebo (sugar pills) and the AOC consisted of two doses (AOC: totals = 1,000mg of vitamin C, 800 IU of vitamin E, and 600 mg of α‐lipoic acid). The FVC/FEV1 (%) was 58±7%. The FMD (%), absolute change in diameter, and FMD/shear was 1.1±0.1 vs. 2.3±1.1%, 0.003±0.000 vs. 0.007±0.003 cm, and 0.12±0.05 vs. 0.17±0.00 au, for the placebo and AOC respectively. Shear (AUC) to peak dilation was 27% greater following antioxidant supplementation when compared with placebo (13569± 6584 vs. 10683± 3697 s−1). In conclusion, there appears to be an improvement in vascular function, measured via FMD, with the ingestion of an antioxidant cocktail in patients with COPD. Supported by TRDRP 15RT‐0100 and Parker B Francis Fellowship.
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