Abstract
A randomly assigned group of 51 mongrel dogs received a total intravenous dose of 1.85 mg of amphotericin B per pound of body weight over a 19-day period. The results of culture examination of lymph nodes for Histoplasma capsulatum were compared with similar cultures from a matched sample of 50 dogs who had received no drugs. A significant difference in infection rates as determined by culture was demonstrated indicating that amphotericin B is capable, at this regimen, of reducing such infection rates by at least 58% Thus, this method of therapy can be recommended as an important and perhaps necessary procedure for researchers utilizing dogs obtained from endemic histoplasma areas. Associations were demonstrated between infection and the results of selected serological tests, with histoplasmin skin test readings, and with histopathologic findings.
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