Abstract
The periodicity of food intake of 10 albino rats was investigated before, during and after exposure to amphetamine. The difference between the cumulative real and average food intake was submitted to autocorrelation for each test period. Before drug exposure, all animals showed a distinct circadian feeding behavior. During the following 7-day period, the animals obtained an amphetamine solution instead of drinking water and thus were submitted to a more or less continuous drug influence. Under amphetamine, no circadian periodicity could be seen. In the succeeding test period, 7 animals showed a reappearance of circadian feeding behavior, whereas in 3 animals no periodicity was evident. The possibility of a link between biological rhythms and homeostatic mechanisms is considered. The author wishes to acknowledge the assistance of the Computing Center of the University of Zurich, especially of Dr. M. Hamza and Mr. K. Kleibohm, who gave their valuable help in the writing and execution of the computer program. The critical revision of the manuscript by Dr. D. A. Yutzey is gratefully acknowledged.
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