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Abstract
The effect of different ions on red cell metabolism has been examined. Ammonium ions have been found to have a specific effect on the hexose monophosphate shunt. This effect has been observed by adding ammonium chloride and ammonium hydroxide to the cells. The stimulative effect of ammonium on the pentose phosphate pathway is an independent phenomenon, not related to increased alkalinity of the medium. Increasing alkalinity, by addition of sodium hydroxide and potassium hydroxide stimulates mainly the anaerobic pathway of glycolysis. The observed effects were found to be not due to changes in ionic strength or in osmolarity of the media.
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