Abstract
Objective To study the renal protection of aminophylline on neonates with asphyxia. Methods 52 neonates with perinatal asphyxia were random divided into experimental group (27 cases) that receive a single dose aminophylline (5mg/kg,) intervenous drop infusion and control group (25 cases) that reveived aqua proinjectione intervenous drop infusion during the first hour of life. The urinary excretion beta 2 micr- oglobulin ( β 2M) was detected for consecutive three days after birth in neonates with asphyxia. Data from two groups were analyzed by statistics.Results There was no statistically significance difference in the levels of β 2 M at 24 hours and 48 hour after birth ( P < 0.05 ) but a statistical significance of 72h after birth (P < 0.01 ) between the experiental group and control group.Conclusios A single dose of aminophylline ( 5mg/kg ) within the first hour of birth in neonates with perinatal asphyxia results in a significant decrease in urinary excretion of β2M. Key words: Newborn infant; Asphyxia; Aminophylline; Renal injury
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