Abstract
The purpose of our study was to determine influence of age on renal prostaglandin (PG) synthesis in man. Urinary prostaglandins 6-Keto-PGF 1α, TxB 2, PGE 2 and PGF 2α were measured in 45 normotensive subjects aged from 20–95 years. Urinary 6-Keto-PGF 1α excretion, reflecting mainly renal cortical prostacyclin synthesis, decreased significantly with age, while urinary TxB 2 showed the opposite development. The ratio of urinary 6-Keto-PGF 1α/TxB 2 decreased with age. PGE 2 excretion was preserved in old subjects probably because the age-dependent decrease in renal function concerns mainly the cortex and spares the medulla. PGF 2α synthesis was least influenced by age. This age-dependent decrease in renal prostacyclin synthesis may play a role in the renal alterations of the elderly.
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