The Influence of Age and Central Foveal Thickness on Foveal Zone Size in Healthy People.

Abstract

To investigate the influence of age and central foveal thickness (CFT) on the foveal avascular zone (FAZ) size in healthy people using optical coherence tomography angiography (OCTA). A cross-section study. One hundred thirty-two healthy subjects (224 eyes) were included. All participants underwent examination with OCTA. CFT and FAZ size, including vertical radius (VR), horizontal radius (HR), and area, were measured. Linear regression analysis showed a positive correlation between age and FAZ size. The HR, VR, and area had an increase of 0.001 mm (P = .002), 0.001 mm (P = .001), and 0.001 mm(2) (P = .000) each year, respectively. There was a negative correlation between CFT and FAZ size. When the CFT increased per 1 µm, the HR, VR, and area decreased by 0.002 mm (P = .000), 0.001 mm (P = .000), and 0.003 mm(2) (P = .000), respectively. FAZ size increases with age and decreases with CFT. OCTA is a novel method to study the FAZ in healthy people.