Abstract
The objective of this study was to assess the static left ventricular diastolic compliance and myocardial water content in adult and immature dogs following 30 min of normothermic (NTH, 37°C) or hypothermic (HTH, 25°C) global myocardial ischemia. Cardiopulmonary bypass was established using 10 adult and 10 immature (10–12 weeks) dogs randomly assigned to 30 min of normothermic or hypothermic global myocardial ischemia. Utilizing ultrasonic dimension crystals, left ventricular end-diastolic minor axis diameter was determined before and after ischemia using a range of filling pressures from 0 to 20 mm Hg. By fitting the end-diastolic data, normalized to a natural strain definition (ϵ), to the equation P = α(e βϵ — 1), the compliance coefficients α and β were determined. In both the adult and immature normothermic arrest groups, the compliance coefficient β increased significantly as follows: 5.54 to 8.94 and 13.17 to 19.97 ( P < 0.05). There were no significant changes in α or β in the hypothermic arrest groups. Myocardial water content in the normothermic group was compared to the hypothermic groups, there were no significant differences. This study suggests that 30 min of warm ischemia adversely affects the adult and immature myocardium equally and the fall in diastolic compliance cannot be attributed to changes in myocardial water content.
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