Abstract
The adsorption of poloxamer block copolymer surfactants onto hydrophobic surfaces is of interest as a means of stabilizing suspensions and creams, and as a research tool for organ‐specific delivery of colloidal particles. In this study, adsorption of poloxamers to a model hydrophobic drug (atovaquone) has been studied at a range of temperatures. It was noted that the adsorption first falls, then rises and falls again as the temperature is increased. As adsorption is generally exothermic, such behaviour is unusual. The explanation for these observations is based on the existence of a phase transition in aqueous solutions of these surfactants at specific temperatures which may be a critical micelle temperature. The observations reported here are of significance for conventional and targeted drug‐delivery systems which include poloxamers. 1995 Royal Pharmaceutical Society of Great Britain
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