Abstract
Summary The 24-h urinary excretion of 52, 7α-dihydroxy-11-ketotetranorprosta-1,16-dioic acid (PGF-M) was measured in thirteen psoriatic patients for 2 days before and 2 days after a single dose of 8-MOP plus UV-A. Before treatment, the excretion of PGF-M was significantly higher in males than females (mean ± s.d.: 26.05 ±8-83 μg/24 h compared to 16.27±5.09 μg/24 h; .P < 0.005). The mean 24-h excretion of PGF-M was not altered significantly for up to 48 h after the single dose of 8-MOP plus UV-A. This is compatible with previous findings that prostaglandin synthesis in the skin is not increased by 8-MOP plus UV-A.
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