Abstract
Objective To explore the protective effect of bamboo leaf flavone in hepatic ischemia-reperfusion injury (HIRI). Methods SD rats were divided into the sham group, the HIRI group and the bamboo leaf flavone intervention group. Rats in bamboo leaf flavone intervention group received bamboo leaf flavone (30 mg/kg) by intraperitoneal injection for 14 consecutive days before establishing the model of hepatic ischemia-reperfusion. Rats in the sham group and the HIRI group received the same volume normal saline. The serum alanine aminotransferase (ALT) and aspertate aminotransferase (AST) were detected. The serum IL-1, IL-6 were detected by ELISA. The expression of caspase-3 in liver tissue was detected by the Western Blot. Results Compared to the HIRI group, the ALT (215.31 ± 52.21 U/L vs. 343.11 ± 78.32 U/L), AST (501.59 ± 70.13 U/L vs. 863.97 ± 63.58 U/L), IL-1 (315.30 ± 88.64 U/L vs. 596.85 ± 102.34 U/L), IL-6 (106.75 ± 10.25 U/L vs. 183.64 ± 20.69 U/L) in the bamboo leaf flavone intervention group significantly decreased (P<0.05). Compared to the HIRI group, expression of caspase-3 (0.38 ± 0.05 vs. 0.86 ± 0.09) in the bamboo leaf flavone intervention group significantly decreased (P<0.05). Conclusions Bamboo leaf flavone pretreatment could reduce HIRI and the mechanism may be associated with inhibiting the expression of caspase-3 protein. Key words: Reperfusion injury; Bamboo leaf flavone; Caspase-3; Rats
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