The Inflammatory Response in Mouse Lung after Acute Sulfur Dioxide Exposure

Abstract

Background: Effect of sulfur dioxide() exposure on airway is well known but little about the effect of exposure on lung parenchyme. This study is to determine if short tenn exposure to in concentration commonly found in industrialized environment cause potentially harmful effect on the lung parenchyme, and to evaluate the exposure time-response relationship between short tenn exposure to and the inflammatory response in mouse lung. Method: 5ppm gas was used and 48 mice were grouped into control(10), 30(9), 60(11), and 120 minute exposure(18) group. In each group, bronchoalveolar lavage(BAL) was done immediately after and at 1,2,3 days after exposure. Histological examination was performed in control and 120 minute exposure group. Results: 1) Cell response in bronchoalveolar lavage fluid. In 30 and 60 minute exposure group, compared to the control group, lymphocyte count has significantly increased(p on the lung parenchyme as well as the airway at exposure level that are regarded as relatively safe, and the duration of injury depends on the exposure time.