The inflammation-resolving tri-hydroxy docosahexaenoic acid derivative, resolvin D2 increases MCF-7 cell number

Abstract

. • Formyl peptide receptors (FPRs) are G-protein coupled receptors. • FPRs can bind a wide range of structurally diverse ligands including proteins, small peptides and bioactive lipid mediators. They are expressed in both estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cell lines. • Some of the endogenous inflammation- resolving FPRs ligands (annexin A1 and its N terminal AC2-26 and the trihydroxy lipid mediator, lipoxin A