Abstract
Although numerous other bioassays are available, the use of in vitro test systems to detect the genotoxic effects of organic airborne particles has been almost exclusively limited to the Salmonella/mammalian microsome (Ames) assay. In addition to using the Ames assay, the present study tested the organic fraction of urban particulate matter in the sensitive sister chromatid exchange (SCE) assay, using cultured human peripheral lymphocytes and hamster lung fibroblast (V79) cells. To provide metabolic activation for detection of promutagens, either liver homogenate from Aroclor-induced rats (S9) or feeder layers of irradiated Syrian hamster fetal cells were added to the V79 system; the S9 fraction was included in the bacterial assay.
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