Abstract
various types of heterologous challenge have also been reported (Rowley, 1955; Landy, 1956a; Dubos and Schaedler, 1957; and others). The purpose of this report is to discuss the nonspecific resistance induced in mice by a substance present in crude commercial preparations of papain. Papain is a proteolytic enzyme prepared from the fruit of the papaya (Carica papaya). This study was initiated when, in the course of various experiments concerning the effect of enzymatic digestion on the immunologic properties of bacterial cells, it was noted that a papain suspension (experimental enzyme control) induced a significant degree of protection in mice challenged with Staphylococcus aureus. In that study it was noted that when 0.5 ^0 papain was injected into mice approximately 60*^0 of the animals survived a
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