Abstract
An in vitro model for the study of the pathogensis of silicosis is described. In it, filtered supernates from alveolar macrophage cultures incubated in contact with silica particles are added to target cultures of lung fibroblasts. The effects of this system are easily studied by observation for cytotoxicity and hydroxyproline production. These results confirm and extend the observations of Heppleston and Styles and point to the use of such a system for the in vitro study of the effects of silica.
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