Abstract
PGF2alpha was administered intravenously to 15 women for induction of therapeutic abortion, missed abortion, or prematurely ruptured membranes. 7 women in the 6th to the 14th weeks of pregnancy were infused with 41 to 55 mcg/minute of PGF2alpha. Uterine response appeared after 10-20 minutes, and contractions became regular after 120-200 minutes. Infusion time ranged from 6 hours 16 minutes-10 hours 36 minutes. In 3 cases there was complete expulsion of fetus and placenta. Diarrhea was seen in all patients; nausea and vomiting appeared in some cases. 8 patients in the 18-29th weeks of gestation were treated with intravenous infusion of 11-33 mcg/min. This small dose cause remarkable contractions, and abortion was successful in all 4 cases of missed abortion, 3 cases of premature rupture of membranes, and 1 case of therapeutic abortion. Blood loss was minimal and there were few side effects. This study shows that intravenous infusion of PGF2alpha for the induction of midtrimester abortion is a safe and more reliable method than hypertonic saline or glucose solution. Vacuum aspiration remains the preferred method for induced abortion in the 1st trimester of pregnancy.
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