Abstract
Stenotrophomonas maltophilia has at least two inducible β-lactamases, L1 and L2, which can hydrolyze almost all classes of β-lactam antimicrobial agents. This study was done to verify the indirect pathogenicity of S. maltophilia that could promote the growth of other β-lactam agent-susceptible bacteria in a mixed culture. We counted CFU of β-lactam agent-susceptible bacteria under the presence of imipenem or ceftazidime in a pure culture and mixed culture with S. maltophilia. Our results showed that β-lactamase leaking from S. maltophilia can encourage the growth of Serratia marcescens and Pseudomonas aeruginosa even if imipenem or ceftazidime was supplemented. This study discovered a blind spot in chemotherapy against an indirect pathogen such as S. maltophilia.
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