Abstract
The indications for RBC transfusions to restore the peripheral red blood cell volume in patients with hypovolemic anemia of trauma to prevent amputations
Highlights
The special review article “Indications for and adverse effects of red cell transfusion” by J.L
In 1969, the Naval Blood Research Laboratory (NBRL) at the Chelsea Naval Hospital, Chelsea, MA reported the increase in red blood cell 2,3 diphosphoglycerate (DPG) and red blood cell creatine levels in patients with red cell mass deficits or cardiopulmonary insufficiency [2]
The data indicated that the red blood cell 2,3 DPG and creatine levels assessed the state of tissue oxygenation and suggested that these two measurements could be use to evaluate the treatment of patients with red cell mass deficits and patients with cardiopulmonary insufficiency
Summary
The special review article “Indications for and adverse effects of red cell transfusion” by J.L. In vivo studies showed that the increased RBC creatine levels observed in patients with chronic hypovolemic anemia of trauma following RBC transfusions to increase the peripheral red blood cell volume to normal were associated with a decrease in the red blood cell creatine levels.
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