Abstract
The aim of the present study is to investigate the relationship between sarcopenia and cardiovascular risk factors (CVRF) in the Chinese elderly. A total of 1611 elderly individuals aged ≥60 years were enrolled in this study. The well-established CVRF of diabetes, hypertensions, and dyslipidemia were assessed. Sarcopenia was defined according to the recommended algorithm of the Asian Working Group for Sarcopenia (AWGS). Multiple logistic regression analyses and the linear regressions were used to evaluate the components of CVRF and the number of CVRF of elderly patients with sarcopenia. After adjusting for potential confounders, CVRF was associated with a high prevalence of sarcopenia in elderly Chinese populations. Furthermore, diabetes and hypertension, but not dyslipidemia, were found to be significantly associated with sarcopenia. The OR and 95% CI for sarcopenia of the participants with 1, 2, and 3 features of CVRF were 2.27(1.14–4.48), 4.13(1.80–9.46), and 4.90(1.01–23.81), respectively. A linear increase in the prevalence of sarcopenia was found to be associated with the number of CVRF components in the elderly population (P values for the trends < 0.001). Knowledge of known CVRF, particularly diabetes and hypertension, may help predict the risk for sarcopenia in the elderly.
Highlights
Sarcopenia is a disease that is characterized by the decline of skeletal muscle mass, muscle strength, and physical performance[1]
The odds ratio (OR) and 95% CI in the adjusted model 3 for the factors that were statistically significantly associated with sarcopenia were 2.66(1.41– 5.01) for cardiovascular risk factors (CVRF), 4.55(2.19–9.47) for diabetes and 1.82(1.02–3.27) for hypertension
We examined the effects of the prevalence of different numbers of CVRF components on sarcopenia using the Asian Working Group for Sarcopenia (AWGS) definition in suburb-dwelling populations of elderly persons aged 60 and older in China
Summary
Sarcopenia is a disease that is characterized by the decline of skeletal muscle mass, muscle strength, and physical performance[1] It is associated with the aging process and can lead to significant morbidity and disability in elderly populations, including loss of independence, poor quality of life, and an increased risk of death[2,3,4,5]. The rate of sarcopenia in the elderly is expected to increase in the future[6] This disease contributes to current increased health care costs[7] and is becoming a major public health problem[8]. One study reported that sarcopenia was closely associated with increased risk factors for CVD18. Few studies have surveyed the comparative significances of these features by the means of structural equation modeling
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