Abstract
SummaryThe hypothesis that pre-eclampsia in pregnant diabetics may be related to the adverse influence of relatively poor diabetic control on the pregnancy-induced changes in the spiral arteries, was examined by comparing mean blood sugar and glycosylated haemoglobin levels throughout the second and third trimesters of pregnancy in two groups of pregnant diabetics, one composed of patients who developed pre-eclampsia and the other of patients who did not. Differences showing poorer control between 11 and 14 weeks in the pre-eclamptic patients were found and this coincided with the time of endovascular trophoblastic invasion of the myometrial segments of these vessels.
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