Abstract
The pathogenic bacterium Klebsiella pneumoniae (KP) is the major causative agent of pyogenic liver abscess (PLA). But reports about the prognosis of KP-caused PLA (KPLA) are rare. This study aimed to ascertain the recurrence rate of KPLA after initial treatment and its contributing factors. A total of 110 patients who had first-time episodes of KPLA were included into the study. The average follow-up time was 3.65 ± 2.18years. Twenty (18.18%) KPLA patients experienced recurrence. Those in the recurrence group had a significantly greater incidence of extended-spectrum β-lactamase (ESBL) production compared with the non-recurrence group (30.0% vs 8.89%, P = 0.018). Diabetes, biliary tract disease, and history of malignancy were not associated with recurrence (all P > 0.05). No difference in the CT characteristics of KPLA (including abscess size, location, whether multilocular, gas production of KPLA, and thrombophlebitis) was found between the two groups. Multivariate regression analysis showed that ESBL production (OR, 6.3; 95% CI, 1.02-38.59; P = 0.04) was an independent risk factor for the recurrence of KPLA. Our findings emphasize that KPLA has a high recurrence rate and ESBL production is an independent risk factor for recurrent KPLA.
Highlights
Background The pathogenic bacteriumKlebsiella pneumoniae (KP) is the major causative agent of pyogenic liver abscess (PLA)
The medical records data were retrospectively analyzed of KP-caused PLA (KPLA) patients who were admitted to Shengjing Hospital of China Medical University from January 2012 to January 2018
Multivariate regression analysis showed that extended-spectrum β-lactamase (ESBL) production (OR, 6.3; 95% CI, 1.02–38.59; P=0.04) was an independent risk factor for the recurrence of KPLA
Summary
Klebsiella pneumoniae (KP) is the major causative agent of pyogenic liver abscess (PLA). This study aimed to ascertain the recurrence rate of KPLA after initial treatment, and its contributing factors. Klebsiella pneumonia-caused pyogenic liver abscess (KPLA) was first discovered in the 1980s in Taiwan and successively reported in mainland China and, as reported cases gradually increased, other countries[1,2,3,4,5]. Klebsiella pneumonia (KP) is the major causative pathogenic bacterium of liver abscess in China[2,3,4, 6, 7]. To date there have been no separate reports on the recurrence rate of KPLA and its contributing factors
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