Abstract
Purpose: To evaluate the efficacy of treatment with dextroamphetamine sulfate for severe idiopathic urgency urinary incontinence refractory to treatment with the selective beta 3 adrenergic agonist, mirabegron. Materials and Methods: Dextroamphetamine sulfate extended release capsule was started at 9.4 mg and increased to 15.7 mg in a woman with two years of severe urgency urinary incontinence. Results: The urgency urinary incontinence completely resolved, as did the fibromyalgia, headaches, and chronic fatigue syndrome. The symptoms have remained eradicated for over one year while treatment continues. Conclusions: Idiopathic urgency urinary incontinence (neurogenic bladder) has been found to be another manifestation of the increased cellular permeability syndrome. Similar to the other chronic disorder associated with the increased cellular permeability syndrome, idiopathic urgency urinary incontinence responds well to dextroamphetamine sulfate treatment despite failure to respond to standard therapy.
Highlights
After two years from the initial diagnosis, the woman developed other symptoms including severe chronic fatigue syndrome, and generalized aches and pains, especially on the right hip, thighs, and legs, and migraine headaches. Her dental hygienist, who was aware through friends that had been treated for the increased cellular permeability syndrome successfully with dextroamphetamine sulfate, referred her to the authors’ practice [15]
The increased cellular permeability syndrome is the etiologic factor for a wide variety of chronic conditions that are refractory to standard therapies that have in common very good improvement following treatment with dextroamphetamine sulfate [15, 16]
Dextroamphetamine sulfate has been found to be highly effective for treating interstitial cystitis [17, 18]
Summary
Summary Purpose: To evaluate the efficacy of treatment with dextroamphetamine sulfate for severe idiopathic urgency urinary incontinence refractory to treatment with the selective beta 3 adrenergic agonist, mirabegron. Materials and Methods: Dextroamphetamine sulfate extended release capsule was started at 9.4 mg and increased to 15.7 mg in a woman with two years of severe urgency urinary incontinence. Results: The urgency urinary incontinence completely resolved, as did the fibromyalgia, headaches, and chronic fatigue syndrome. The symptoms have remained eradicated for over one year while treatment continues. Conclusions: Idiopathic urgency urinary incontinence (neurogenic bladder) has been found to be another manifestation of the increased cellular permeability syndrome. Similar to the other chronic disorder associated with the increased cellular permeability syndrome, idiopathic urgency urinary incontinence responds well to dextroamphetamine sulfate treatment despite failure to respond to standard therapy
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