Abstract
BackgroundHip fracture in the elderly is a health burden worldwide due to its high mortality rate. This study was conducted to determine the possible mechanisms of osteopontin (OPN) and β‐carboxy‐terminal cross‐linking telopeptide of type I collagen (β‐CTX) in hip fracture in the elderly.Materials and MethodsIn the study, we recruited 108 elderly patients with hip fracture diagnosed from May 2012 to May 2015 at the Third Hospital of Xiamen and 86 healthy individuals without a history of hip fracture were taken as controls. Serum levels of OPN and β‐CTX were then determined. The T and Z values for bone mineral density (BMD) were also measured. Moreover, logistic regression analysis was performed to assess the risk and protective factors for hip fracture in the elderly.ResultsSerum levels of both OPN and β‐CTX were increased in elderly patients with hip fracture. OPN was positively correlated with β‐CTX. In addition, the levels of OPN and β‐CTX shared a positive association with the age, and a negative association with the BMD, in terms of T and Z values of the hip. In addition, increased BMD and outdoor sports might be protective factors for hip fracture, and an increase in levels of OPN and β‐CTX might be associated with a higher risk of hip fracture in the elderly population.DiscussionCollectively, increased serum levels of OPN and β‐CTX might be correlated with a higher risk of a hip fracture and have predictive values in the occurrence of hip fracture in the elderly.
Highlights
Hip fracture represents a serious health risks that frequently occurs in the elderly population.[1]
The results suggested a positive correlation between OPN and β-carboxy-terminal cross-linking telopeptide of type I collagen (β-CTX) levels and age (r = .444, P < .001; r = .274, P = .004), and a negative correlation between OPN and β-CTX levels and bone mineral density (BMD) (r = −.375, P < .001; r = −.198, P = .040), T value (r = −.209, P = .030; r = −.241, P = .012) and Z value (r = −.216, P = .025; r = −.224, P = .020) in TA B L E 2 Serum levels of OPN and β-CTX share a positive association with the age in old patients with hip fracture
Experimental results suggest that serum levels of OPN and β-CTX are independent predictors for the risk of hip fracture
Summary
Hip fracture represents a serious health risks that frequently occurs in the elderly population.[1]. Age has been shown to be a major risk factor, and the incidence of hip fracture is increasing with an aging population.[4]. Recent studies have reported that bone mineral density (BMD) and hip geometry along with the T- or Z-score for BMD are independently associated with an increased risk of hip fracture.[5,6]. Osteopontin (OPN) is a protein made by bone tissues which plays a pivotal role in wound repair.[8]. Another study concluded that increased serum levels of OPN are correlated with prevalent fractures in postmenopausal women with type 2 diabetes.[11]. A study revealed that a high serum level of β-CTX is an independent factor in aggravating hip fracture.[14]. Little is known about the synchronous role of OPN and β-CTX in elderly patients with a hip fracture; the study aims to identify potential mechanistic interplays between OPN and β-CTX based on their serum levels in elderly patients with hip fracture
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
