Abstract
Aging of special female germ-cell stages, but not of the females themselves, is responsible for an increase in the frequency of X-chromosomal aneuploids (XO, XXY) in Drosophila melanogaster. Two requirements have to be met to demonstrate that age effect: (1) reduction of oviposition during the aging of the females (to allow aging of the germ cells by arrest of oogenesis), and (2) performance of a detailed brood pattern analysis after the aging procedure. The second parameter seems to influence more the frequency of XO than that of XXY exceptions. Early oocytes and late oogonia are probably the germ-cell stages that respond most strongly to an arrest of oogenesis by a rise in the frequency of XO individuals in the offspring derived from them.
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