Abstract
Chitosan-covered calcium phosphate nanoparticles with the mean dynamic radii of 30 to 130 nm and ζ-potential of +22 ± 4 mV containing timolol and lisinopril are prepared and characterized. These particles are formed by the amorphous phase represented by amorphous calcium phosphate Ca x (PO4) y · zH2O and the crystalline phase represented by hydrated calcium hydrophoshate (brushite) CaHPO4 · 2H2O. The experiments in vivo demonstrated that the inclusion of timolol into calcium phosphate particles covered with chitosan substantially prolonged its effect on the intraocular pressure.
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