Abstract
BackgroundObesity is a major public health problem in many poor countries where micronutrient deficiencies are prevalent. A partial meal replacement may be an effective strategy to decrease obesity and increase micronutrient intake in such populations. The objective was to evaluate the efficacy of a partial meal replacement with and without inulin on weight reduction, blood lipids and micronutrients intake in obese Mexican women.MethodsIn a randomized controlled clinical trial 144 women (18–50 y) with BMI ≥ 25 kg/m2, were allocated into one of the following treatments during 3 months: 1) Two doses/d of a partial meal replacement (PMR), 2) Two doses/d of PMR with inulin (PMR + I) , 3) Two doses/d of 5 g of inulin (INU) and 4) Control group (CON). All groups received a low calorie diet (LCD). Weight, height, hip and waist circumference were measured every 2 weeks and body composition, lipids and glucose concentration and nutrient intake were assessed at baseline and after 3 months.ResultsAll groups significantly reduced weight, BMI, waist and hip circumference. Differences between groups were only observed in BMI and weight adjusted changes: At 45 days PMR group lost more weight than INU and CON groups by 0.9 and 1.2Kg, respectively. At 60 days, PMR + I and PMR groups lost more weight than in INU by 0.7 and 1Kg, respectively. Subjects in PMR, PMR + I and INU significantly decreased triglycerides. Energy intake was reduced in all groups. Fiber intake increased in PMR + I and INU groups. Some minerals and vitamins intakes were higher in PMR and PMR + I compared with INU and CON groups.ConclusionInclusion of PMR with and without inulin to a LCD had no additional effect on weight reduction than a LCD alone but reduced triglycerides and improved intake of micronutrients during caloric restriction. PMR could be a good alternative for obese populations with micronutrient deficiencies.ClinicalTrials.Gov IDNCT01505023
Highlights
The prevalence of obesity is increasing in many countries and has become a public health challenge in populations worldwide
The objective of this study was to test the efficacy of a Partial meal replacements (PMR) added with vitamins, minerals and inulin on weight reduction, blood lipids and micronutrients intake in obese Mexican women
The Low calorie diets (LCD) consisted of educating subjects in detail with a printed guideline developed according with the official food guide for Mexican population (NOM-043-SSA2-2005) and with the National Institutes of Health guide to treat overweight and obese adults [24]
Summary
The prevalence of obesity is increasing in many countries and has become a public health challenge in populations worldwide. Recent studies have suggested that micronutrient deficiencies might be associated with a higher susceptibility for obesity which might partially explain why obesity in poor countries has increased more rapidly [5]. The possible association of some micronutrient deficiencies with a higher susceptibility for fat deposition and obesity has recently been revised [6]. Obesity is a major public health problem in many poor countries where micronutrient deficiencies are prevalent. A partial meal replacement may be an effective strategy to decrease obesity and increase micronutrient intake in such populations. The objective was to evaluate the efficacy of a partial meal replacement with and without inulin on weight reduction, blood lipids and micronutrients intake in obese Mexican women. Height, hip and waist circumference were measured every 2 weeks and body composition, lipids and glucose concentration and nutrient intake were assessed at baseline and after 3 months
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